¹Chemistry Department / Faculty of Science / University of Zakho ²Chemistry Department/ Faculty of Science/ University of Duhok Kurdistan region / Iraq

*Corresponding Author E-mail: caser.abdel@yahoo.com

Accepted 23rd January, 2016.

Naproxen amino acid ester (2a-b) prepared by the reaction of naproxen with amino acid esters. Hydrazides (3a-b) were obtained by reaction of corresponding esters with hydrazine hydrate. These hydrazides were used to synthesize a series of five membered ring heterocyclic compounds, the hydrazides (3a-b) were converted to 1,3,4-oxadiazole-2-thione (4a-b) by their reaction with carbon disulfide in ethanolic potassium hydroxide. 2,5-Disubstituted 1,3,4-oxadiazole (6a-b) were obtained from the reaction of lead oxide with naproxen amino acid hydrazone (5a-b) where hydrazone prepared from the reaction of hydrazides (3a-b) with p-nitrobenzaldehyde. Mono substituted 1,3,4-oxadiazole (8a-b) were synthesized from the reaction of 2-formyl hydrazine (7a-b) with Phosphorous pentoxide. Finally, 4-amino 1,2,4-triazol-5-thiol (10a) was prepared from the reaction of dithiocarbazate salt with hydrazine hydrate. The structures of synthesized compounds were confirmed by physical and spectral means.

Keywords: Synthesis, Drugs, Hydraxide

How To Cite This Article:

Huda A. Basheer¹, Maysoon S. Ahmed¹, Layla A. Othma². Synthesis of Some New Oxadiazole and Tetrazole Derived from Naproxen Drugs. Swift Journal of Pharmacy and Pharmacology 1(1), pp. 011-015.